Fe: Interferes absorption of oral tetracycline antibiotics. Concurrent administration w/ penicillamine & antacid may impair absorption. Folic acid: Drugs that may cause folate deficiency including phenytoin, INH, primidone, barbiturates, OCs, ethanol, sulfasalazine, cycloserine, glutethamide, MTX, pyrimethamine, trimethoprim & triamterene. Zn: Interferes w/ tetracycline antibiotics, thiazide & K-sparing diuretics absorption. Decreased absorption & effectiveness of fluoroquinolones; Fe supplement; lansoprazole, omeprazole, pantoprazole, rabeprazole; Al or Mg-containing antacids; alendronate, etidronate, risedronate; cimetidine, famotidine, nizatidine, ranitidine; penicillamine; ciprofloxacin, gatifloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, ofloxacin, sparfloxacin, trovafloxacin.
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